Plasma pTau217 as a Strong Predictor of Alzheimer's Disease in the Korean Population

This study confirmed the potential of plasma biomarkers, particularly pTau217, in predicting amyloid positivity and AD progression in the Korean population. Plasma pTau217 emerged as the most robust plasma biomarker for detecting amyloid positivity, outperforming GFAP and NfL. These findings suggest that pTau217 may serve as a reliable cross-ancestry plasma biomarker for predicting the early development of amyloid positivity before onset of cognitive symptoms.