The current state of the screening and enrollment pipeline for clinical research engagement in the era of disease modifying therapies for Alzheimer’s disease

This data suggests that increasing the pipeline of potential research participants for clinical trials should focus on continued efforts to destigmatize clinical trial engagement, adapt inclusion/exclusion criteria to allow concomitant disease-modifying therapies, and eliminate unnecessary exclusion criteria if it does not affect safety and or primary outcome measures.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70859_106302
Primary Topic
Ethics in Clinical Research
Type
article
Field-Weighted Citation Impact
0.00
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article

The current state of the screening and enrollment pipeline for clinical research engagement in the era of disease modifying therapies for Alzheimer’s disease

A. G. Shaffer, Gregory A. Jicha, Alexandra Curtis, Laura Clewett et al.
Alzheimer s & Dementia
Ethics in Clinical Research
article

The current state of the screening and enrollment pipeline for clinical research engagement in the era of disease modifying therapies for Alzheimer’s disease

A. G. Shaffer, Gregory A. Jicha, Alexandra Curtis, Laura Clewett, Muna Amry, M. K. Harper, Rosmy George, Lauren Bojarski, Elif Coşkun, Melanie G Elam, Shreeya Shrestha
article en

Abstract

This data suggests that increasing the pipeline of potential research participants for clinical trials should focus on continued efforts to destigmatize clinical trial engagement, adapt inclusion/exclusion criteria to allow concomitant disease-modifying therapies, and eliminate unnecessary exclusion criteria if it does not affect safety and or primary outcome measures.

Alzheimer s & DementiaVol. 21(S5)
University of Kentucky (US)
Reduced inequalities
Openalex Percentile: Top 26%
Ethics in Clinical Research
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