Identification of candidate serum protein biomarkers in Down's syndrome dementia

Several of the differentially expressed proteins identified in this study have previously been linked as risk factors for Alzheimer disease and are components of functional pathways thought to contribute to the pathogenesis of AD and DSAD. These pathways include immune cell activation, reverse cholesterol transport, regulator of iron homeostasis and inhibition of Ab fibrils and oligomers. Furthermore, the significant difference of concentrations of these proteins in the sera of DS individuals may be further developed to generate non-invasive methods to identify and track the progression of AD, even in the prodromal phases.