Validation of Amyloid Chronicity in Autosomal Dominant Alzheimer Disease
SILA produces a valid estimate of time-from-amyloid positivity in ADAD. This work allows for disease stage in ADAD to be compared to staging for broad forms of AD, which was not previously possible using EYO. However, this work also illustrates that there is a high degree of heterogeneity in preclinical disease duration that is not explained by amyloid alone.
Authors
- Nicole S. McKay (ORCID: https://orcid.org/0000-0003-4123-2548)
- Tobey J. Betthauser (ORCID: https://orcid.org/0000-0001-8856-1352)
- Jeremy F. Strain (ORCID: https://orcid.org/0000-0002-8381-8646)
- Zahra Shirzadi (ORCID: https://orcid.org/0000-0001-6854-9356)
- David Fernando Aguillon (ORCID: https://orcid.org/0000-0003-2283-536X)
- Johannes Levin (ORCID: https://orcid.org/0000-0001-5092-4306)
- Peter R Millar (ORCID: https://orcid.org/0000-0003-4588-739X)
- Alisha Daniels (ORCID: https://orcid.org/0009-0001-1464-6465)
- Stephanie A. Schultz (ORCID: https://orcid.org/0000-0001-8460-4415)
- Matthew Zammit (ORCID: https://orcid.org/0000-0001-8966-8397)
- Julie K. Wisch (ORCID: https://orcid.org/0000-0003-3624-2784)
- Patricio Chrem
- J.R Lee
- Eric McDade (ORCID: https://orcid.org/0000-0002-6764-3866)
- Beau M. Ances (ORCID: https://orcid.org/0000-0003-3862-7397)
- Natalie S. Ryan (ORCID: https://orcid.org/0000-0003-0361-7455)
- Jasmeer P. Chhatwal (ORCID: https://orcid.org/0000-0002-7792-1698)
- Jorge J. Llibre‐Guerra (ORCID: https://orcid.org/0000-0002-2137-7750)
- Bradley T Christian
- Mathias Jucker
- Laura Ibanez
- Nelly Joseph‐Mathurin
- Charlene Supnet‐Bell
- Lisa Vermunt
- Guoqiao Wang
- Gregory S Day
- Yan Li
- Robert A. Koeppe
- Chengjie Xiong
- Carlos Cruchaga
- Jee Hoon Roh
- Brian A. Gordon
- Tammie L.S. Benzinger
- Alan E. Renton
- Nicolas R. Barthélemy
- Suzanne E. Schindler
- Clifford R. Jack
- John C. Morris
- The Dominantly Inherited Alzheimer Network (DIAN)
- Randall J. Bateman
Institutions
- Ulsan College (KR)
- Brigham and Women's Hospital (US)
- University of Wisconsin–Madison (US)
- Harvard University (US)
- Washington University in St. Louis (US)
- University of Michigan (US)
- German Center for Neurodegenerative Diseases (DE)
- Jacksonville College (US)
- Asan Medical Center (KR)
- LMU Klinikum (DE)
- Universidad de Antioquia (CO)
- University of Ulsan (KR)
- Massachusetts General Hospital (US)
- Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia (AR)
- Amsterdam Neuroscience (NL)
- Hope Center for Neurological Disorders (US)
- Mayo Clinic in Arizona (US)
- UK Dementia Research Institute (GB)
- Mayo Clinic in Florida (US)
- Wisconsin Division of Public Health (US)
- University College London (GB)
- Ludwig-Maximilians-Universität München (DE)
- Vrije Universiteit Amsterdam (NL)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_103008
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00