Relation of the kynurenine pathway with cognitive functioning and differences in patients with cognitive impairment or dementia: a systematic review and meta‐analysis
These results suggest that AD dementia is associated with lower blood levels of several KP metabolites. Findings also challenge assumptions that neurotoxic quinolinic acid levels are an important contributor to dementia pathogenesis.
Authors
- Bart P. F. Rutten (ORCID: https://orcid.org/0000-0002-9834-6346)
- Daniël van den Hove (ORCID: https://orcid.org/0000-0003-4047-3198)
- Lieke Bakker (ORCID: https://orcid.org/0000-0002-2160-7018)
- Kyonghwan Choe (ORCID: https://orcid.org/0000-0001-9150-0155)
- Simone J. P. M. Eussen (ORCID: https://orcid.org/0000-0003-0559-6838)
- Sebastian Köhler (ORCID: https://orcid.org/0000-0002-2398-0609)
- Frans R.J. Verhey
- Gunter Kenis
- Inez H.G.B. Ramakers
Institutions
- Transnational University Limburg (NL)
- Maastricht University (NL)
- European Graduate School of Neuroscience (NL)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_102238
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00