<i>APOE</i> ɛ4 carriership determines a faster plasma p‐tau217 progression in Aβ‐positive individuals
Blood phosphorylated tau (p-tau)217 increases faster in apolipoprotein E (APOE) ɛ4 carriers with amyloid pathology. p-tau181 and p-tau231 do not increase faster in APOE ɛ4 carriers. APOE ɛ4 carriership does not change p-tau in individuals without amyloid pathology.
Authors
- Tharick Ali Pascoal (ORCID: https://orcid.org/0000-0001-9057-8014)
- Nesrine Rahmouni
- Marcel S. Woo (ORCID: https://orcid.org/0000-0002-1306-2708)
- Gassan Massarweh (ORCID: https://orcid.org/0000-0003-2259-9627)
- Jaime Fernandez‐Arias
- Arthur C. Macedo (ORCID: https://orcid.org/0000-0002-3957-0284)
- Tevy Chan (ORCID: https://orcid.org/0009-0001-9134-5949)
- Firoza Zubeida Lussier (ORCID: https://orcid.org/0000-0002-6877-4825)
- Robert Hopewell (ORCID: https://orcid.org/0000-0002-2478-5872)
- Kaj Blennow
- Yansheng Zheng
- Yi‐Ting Wang
- Cécile Tissot (ORCID: https://orcid.org/0000-0002-5022-2213)
- Serge Gauthier
- Jenna Stevenson (ORCID: https://orcid.org/0000-0003-2848-1451)
- Lydia Trudel (ORCID: https://orcid.org/0009-0002-5593-7717)
- Stuart William Mitchell
- Jean‐Paul Soucy
- Joseph Therriault
- Kely Quispialaya‐Socualaya
- Stijn Servaes
- Seyyed Ali Hosseini
- Marina Goncalves
- Étienne Aumont
- Pedro Rosa‐Neto
- Gleb Bezgin
- Brandon Hall
- Henrik Zetterberg
- Paolo Vitali
- Andréa L. Benedet
Institutions
- Montreal Neurological Institute and Hospital (CA)
- Allen Institute for Brain Science (US)
- Lawrence Berkeley National Laboratory (US)
- Universität Hamburg (DE)
- University of Pittsburgh (US)
- Sahlgrenska University Hospital (SE)
- Alzheimer’s Disease Neuroimaging Initiative (US)
- University Medical Center Hamburg-Eppendorf (DE)
- UK Dementia Research Institute (GB)
- Institute of Neuroimmunology of the Slovak Academy of Sciences (SK)
- University College London (GB)
- McGill University (CA)
- University of Gothenburg (SE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz.71048
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00