Tumour budding in pretreatment cervical biopsies: a prognosticator for personalised therapy in the era of precision oncology

This study is the first to suggest TB in pretreatment biopsy specimens as a reliable morphologic prognosticator in cervical cancer. TME features may enhance precision oncology by offering insights into the individual tumour biology. The fact that these morphologic features are available from routine H&E slides, reserving immunohistochemistry or molecular analysis for indeterminate cases, is of particular value in low-resource settings where the burden of cervical cancer is most significant.

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Publication Details

Journal
Histopathology
Published
2025-12-25
DOI
https://doi.org/10.1111/his.70053
Primary Topic
Endometrial and Cervical Cancer Treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

Tumour budding in pretreatment cervical biopsies: a prognosticator for personalised therapy in the era of precision oncology

Yeon‐Sil Kim, Sung Hak Lee, C. J. Kim, Y. Lee et al.
Histopathology
Endometrial and Cervical Cancer Treatments
article

Tumour budding in pretreatment cervical biopsies: a prognosticator for personalised therapy in the era of precision oncology

Yeon‐Sil Kim, Sung Hak Lee, C. J. Kim, Y. Lee, N Bizzarri, Sea‐Won Lee, Kwangil Yim, Tiara Bunga Mayang Permata, Jin‐Hwi Kim, Songmi Jeong
article en

Abstract

This study is the first to suggest TB in pretreatment biopsy specimens as a reliable morphologic prognosticator in cervical cancer. TME features may enhance precision oncology by offering insights into the individual tumour biology. The fact that these morphologic features are available from routine H&E slides, reserving immunohistochemistry or molecular analysis for indeterminate cases, is of particular value in low-resource settings where the burden of cervical cancer is most significant.

HistopathologyVol. 88(5)
Agostino Gemelli University Polyclinic (IT), St. Mary's Hospital (US), The Catholic University of Korea Uijeongbu St. Mary's Hospital (KR), Rumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo (ID), The Catholic University of Korea Seoul St. Mary's Hospital (KR), Catholic University of Korea (KR)
Reduced inequalities
Openalex Percentile: Top 26%
Endometrial and Cervical Cancer Treatments
DOISourceOpenAlex
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