Differential effects of sex on amyloid lowering by Aducanumab and IgG in 5xFAD mice
Sex-dependent differential clearance of amyloid plaques with monoclonal antibody treatment has been observed translationally across species. The interaction with IgG may contribute to both the amyloid-lowering effects and possibly to the reported adverse events. Results from this study will inform future MODEL-AD PTC evaluations of novel therapeutics, particularly those combined with or following anti-Aβ immunotherapies once amyloid is lowered and the disease continues to progress, and importantly to identify and predict differential effects of sex.
Authors
- Scott A. Persohn
- Gabriela Little
- Sean-Paul G. Williams (ORCID: https://orcid.org/0000-0002-5680-7730)
- Z. Cope
- Suzanne Doolen (ORCID: https://orcid.org/0000-0003-1843-7510)
- Sara K. Quinney (ORCID: https://orcid.org/0000-0002-6554-0695)
- Michael Sasner (ORCID: https://orcid.org/0000-0002-6612-6111)
- Lais Da Silva (ORCID: https://orcid.org/0000-0003-3649-3292)
- Ravi S. Pandey (ORCID: https://orcid.org/0000-0001-9567-2851)
- Kierra Eldridge
- Paul R. Territo (ORCID: https://orcid.org/0000-0003-0460-332X)
- Emma Doud
- Umesh Nepali
- Adrian L Oblak
- Stacey J Sukoff Rizzo
- Kathryn A Haynes
- Bruce T. Lamb
- Charlie P Burton
- Gregory W Carter
Institutions
- University of Pittsburgh (US)
- Jackson Laboratory (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70859_105982
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00