Differential complement pathways and components in the clinical spectrum of systemic lupus erythematosus
The CP is predominantly activated at disease onset, whereas the AP contributes to both initiation and progression of SLE. C2 and FD hold potential as biomarkers for SLE complications. Complement-driven stratification informs precision therapy in SLE.
Authors
- MINGHAO GUO
- Huifang Li
- Haijun Ma
- Qingfeng Yin
Institutions
- University Health Network (CA)
- Toronto Western Hospital (CA)
- First Affiliated Hospital of Xinxiang Medical University (CN)
Publication Details
- Journal
- Arthritis Research & Therapy
- Published
- 2025-12-26
- DOI
- https://doi.org/10.1186/s13075-025-03721-6
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00