Association of COVID‐19 Positivity with Biomarkers of Alzheimer's Disease and Cognitive Test Performance
Overall, we did not find significant associations between COVID-19, cognitive test scores, or biomarker levels. Our data may be less robust given the high percentage of vaccinations among COVID-19 positive cases and that vaccination decreases infection severity. It is also possible that the slightly younger age of the COVID+ group acted as a confounding variable. Strengths of our study include comparison of individual biomarker data before and after the spread of COVID-19, interpretation of individual cognitive test scores relative to previous performance, and a large cohort size enriched with Alzheimer's disease risk factors.
Authors
- Randall S. Johnson (ORCID: https://orcid.org/0000-0002-4084-6639)
- Rachel Studer (ORCID: https://orcid.org/0000-0002-4321-6210)
- Elizabeth M. Planalp (ORCID: https://orcid.org/0000-0001-9219-0806)
- Erin M. Jonaitis (ORCID: https://orcid.org/0009-0004-5091-8255)
- Rachael E. Wilson (ORCID: https://orcid.org/0000-0003-4197-7777)
- Ramiro Eduardo Rea Reyes (ORCID: https://orcid.org/0000-0001-9749-282X)
- Rebecca E. Langhough
- Sarah A Scalzo
- Elias G Seath
Institutions
- University of Wisconsin–Madison (US)
- University of Wisconsin Health (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_102887
- Primary Topic
- Long-Term Effects of COVID-19
- Type
- article
- Field-Weighted Citation Impact
- 0.00