Accelerated rate of plasma <i>p</i> ‐Tau217 progression in amyloid‐β APOE ɛ4 carriers
In the presence of amyloidosis, APOEɛ4 carriers accelerate the plasma p-tau217 progression. In contrast, ɛ4 carriership in A+ individuals did not correlate with rates of p-tau181 and p-tau231. An additive interaction between APOEɛ4 carriership and Aβ status was observed. Further investigation is needed to understand the association between APOEɛ4 carriers and AD biomarkers progression.
Authors
- Nesrine Rahmouni
- Marcel S. Woo (ORCID: https://orcid.org/0000-0002-1306-2708)
- Jaime Fernández Arias (ORCID: https://orcid.org/0000-0002-6810-5920)
- Tevy Chan (ORCID: https://orcid.org/0009-0001-9134-5949)
- Yansheng Zheng
- Tissot Cecile
- J. K. M. ller Stevenson
- Yi‐Ting Wang
- Lydia Trudel (ORCID: https://orcid.org/0009-0002-5593-7717)
- Arthur Macedo
- Marina P Gonçalves
- Etienne Aumont
- Henrik Zetterberg
- Jean‐Paul Soucy
- Joseph Therriault
- Seyyed Ali Hosseini
- Firoza Z Lussier
- Stijn Servaes
- Gleb Bezgin
- Paolo Vitali
- Gassan Massarweh
- Kely Monica Quispialaya Socualaya
- Brandon J Hall
- Pedro Rosa‐Neto
Institutions
- Montreal Neurological Institute and Hospital (CA)
- Lawrence Berkeley National Laboratory (US)
- Universität Hamburg (DE)
- University of Pittsburgh (US)
- McGill University Health Centre (CA)
- Profu (Sweden) (SE)
- University Medical Center Hamburg-Eppendorf (DE)
- McGill Genome Centre (CA)
- McGill University (CA)
- University of Gothenburg (SE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_102950
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00