Protein kinase R-like ER kinase (PERK) is involved in the endoplasmic reticulum stress response of its psyllid vector to <i>Candidatus Liberibacter solanacearum</i> infection

This study provides valuable insights into how vector-borne pathogens manipulate host cellular pathways to promote their survival and transmission. <i>Candidatus Liberibacter solanacearum</i> (CLso) and <i>C. L. asiaticus</i> (CLas) cause severe plant diseases, such as zebra chip in potatoes, carrot yellows, and huanglongbing (citrus greening), posing significant threats to global agriculture. By revealing the role of PERK and the unfolded protein response (UPR) in CLso-induced apoptosis, our findings contribute to the growing understanding of insect immunity and pathogen-host interactions. Understanding how CLso influences ER stress and immune signaling in its psyllid vector could lead to innovative strategies to disrupt pathogen persistence and transmission, ultimately supporting disease management efforts.