Effects of β-hydroxy-β-methylbutyrate on skeletal muscle loss in a mouse model of esophageal squamous cell carcinoma
HMB administration to ESCC-bearing mice maintained grip strength and gastrocnemius muscle weight at levels comparable to those of non-transplanted (non-ESCC) mice. Future studies should elucidate the mechanisms by which HMB counteracts cachexia and confirm these physiological findings with molecular biological evidence.
Authors
- Yoshiaki Shoji (ORCID: https://orcid.org/0000-0003-3074-1398)
- Yamato Ninomiya
- Takayuki Nishi
- Kohei Tajima
- Kohei Kanamori
- Masaki Mori
- Miho Yamamoto
- Kazuo Koyanagi
- Akihito Kazuno
- Rie Nakashima
Institutions
- Tokai University (JP)
Publication Details
- Journal
- Annals of Translational Medicine
- Published
- 2025-12-01
- DOI
- https://doi.org/10.21037/atm-25-126
- Primary Topic
- Muscle metabolism and nutrition
- Type
- article
- Field-Weighted Citation Impact
- 0.00