AutoML‐Multiverse: Model Agnostic Framework for Optimizing Individual‐level Alzheimer's Disease Classification

Preliminary findings reveal three key strengths of the AutoML-multiverse framework: (1) superior predictive performance over individual pipelines, (2) data-driven ensemble construction that reduces biases and arbitrary decisions, and (3) clinically relevant integration of neuroimaging, particularly for distinguishing slow from fast progressors, with potential utility in clinical trials. Future work will validate the robustness and generalisability of these results.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70856_102543
Primary Topic
Dementia and Cognitive Impairment Research
Type
article
Field-Weighted Citation Impact
0.00
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article

AutoML‐Multiverse: Model Agnostic Framework for Optimizing Individual‐level Alzheimer's Disease Classification

Robert Leech, Pedro F. da Costa, Maitrei Kohli, James H. Cole
Alzheimer s & Dementia
Dementia and Cognitive Impairment Research
article

AutoML‐Multiverse: Model Agnostic Framework for Optimizing Individual‐level Alzheimer's Disease Classification

Robert Leech, Pedro F. da Costa, Maitrei Kohli, James H. Cole
article en

Abstract

Preliminary findings reveal three key strengths of the AutoML-multiverse framework: (1) superior predictive performance over individual pipelines, (2) data-driven ensemble construction that reduces biases and arbitrary decisions, and (3) clinically relevant integration of neuroimaging, particularly for distinguishing slow from fast progressors, with potential utility in clinical trials. Future work will validate the robustness and generalisability of these results.

Alzheimer s & DementiaVol. 21(S2)
King's College London (GB), The London College (GB), University College London (GB)
Openalex Percentile: Top 33%
Dementia and Cognitive Impairment Research
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