Evidence for protective and deleterious microglial phenotypes in an individual underscores microglia as an attractive therapeutic target

There may be protective and deleterious microglial phenotypes in an individual, region specific and disease stage dependent. Therapeutic modulation of microglia is warranted to promote anti-inflammatory functions while suppressing pro-inflammatory functions.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70856_103454
Primary Topic
Neuroinflammation and Neurodegeneration Mechanisms
Type
article
Field-Weighted Citation Impact
0.00
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article

Evidence for protective and deleterious microglial phenotypes in an individual underscores microglia as an attractive therapeutic target

Paul Edison
Alzheimer s & Dementia
Neuroinflammation and Neurodegeneration Mechanisms
article

Evidence for protective and deleterious microglial phenotypes in an individual underscores microglia as an attractive therapeutic target

Paul Edison
article en

Abstract

There may be protective and deleterious microglial phenotypes in an individual, region specific and disease stage dependent. Therapeutic modulation of microglia is warranted to promote anti-inflammatory functions while suppressing pro-inflammatory functions.

Alzheimer s & DementiaVol. 21(S2)
Imperial College London (GB)
No poverty
Openalex Percentile: Top 38%
Neuroinflammation and Neurodegeneration Mechanisms
DOIOpen Access PDFOpenAlex
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Evidence for protective and deleterious microglial phenotypes in an individual underscores microglia as an attractive therapeutic target — Paul Edison · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS