Cerebrospinal fluid proteome alterations related to depressive symptoms in cognitive decline and Alzheimer's disease
This is the first study to investigate cerebrospinal fluid proteome alterations associated with depressive symptoms in the context of cognitive decline and Alzheimer's disease (AD). Dysregulated proteins in patients with higher depression scores were related to pathways linked to cell adhesion/inflammation, synaptic signaling, and neurogenesis, as well as cholesterol metabolism in amyloid-positive individuals. The identified proteome alterations may represent shared biological mechanisms involved in both AD and depression in older people.
Authors
- Johannes Streffer
- Julius Popp (ORCID: https://orcid.org/0000-0002-0068-0312)
- Miriam Rabl (ORCID: https://orcid.org/0000-0002-3189-6554)
- Lutz Froelich (ORCID: https://orcid.org/0000-0003-1494-0813)
- S. P. F. Vos
- Yvonne Freund‐Levi
- Rik Vandenberghe
- Magda Tsolaki
- Johan Gobom
- Simon Lovestone
- Charlotte E. Teunissen
- Betty M. Tijms
- Lars Bertram
- Willem L. Hartog
- Henrik Zetterberg
- Yolande A. L. Pijnenburg
- Wiesje M. van der Flier
- Pieter Jelle Visser
Institutions
- Lundbeck (Denmark) (DK)
- University of Wisconsin–Madison (US)
- Janssen (Belgium) (BE)
- University of Antwerp (BE)
- Aristotle University of Thessaloniki (GR)
- Heidelberg University (DE)
- Örebro University (SE)
- Sahlgrenska University Hospital (SE)
- University Hospital Heidelberg (DE)
- Karolinska Institutet (SE)
- Maastricht University (NL)
- University of Oxford (GB)
- Stockholm South General Hospital (SE)
- University Hospital of Zurich (CH)
- Central Institute of Mental Health (DE)
- Amsterdam Neuroscience (NL)
- UK Dementia Research Institute (GB)
- Örebro University Hospital (SE)
- Alzheimer Nederland (NL)
- Johnson & Johnson (United Kingdom) (GB)
- GGD Amsterdam (NL)
- Greek Association of Alzheimer's Disease and Related Disorders (GR)
- University College London (GB)
- Vrije Universiteit Amsterdam (NL)
- University of Gothenburg (SE)
- University of Lübeck (DE)
- University of Lausanne (CH)
- KU Leuven (BE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz.71054
- Citations
- 1
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- National Science Foundation
- Eli Lilly and Company
- Biogen
- Stiftelsen för Gamla Tjänarinnor
- EU Joint Programme – Neurodegenerative Disease Research
- European Federation of Pharmaceutical Industries and Associations
- Noaber Foundation
- Roche Nederland
- European Commission
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- ZonMw
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Eisai
- Vetenskapsrådet
- Universität Zürich
- Hersenstichting
- Alzheimerfonden
- Innovatiefonds Zorgverzekeraars
- Stichting Dioraphte
- Alzheimer Nederland
- Amsterdam Neuroscience
- Bentham-Moxon Trust
- GIESKES-STRIJBIS FONDS
- Avid Radiopharmaceuticals
- HORIZON EUROPE Framework Programme