Investigating Disparities in Metabolite Concentrations Using Gas Chromatography Mass Spectroscopy Among Patients with Alzheimer's Disease and Healthy Subjects

According to our research, Alzheimer's disease is linked to elevated levels of glycine and aspartate and decreased levels of phenylalanine, tyrosine, methionine, and tryptophan. These amino acid disturbances are associated with cognitive deterioration, implying that they might be used as biomarkers for Alzheimer's disease diagnosis and treatment. Supplementing with amino acids may be a viable strategy to slow the decline of cognitive function in AD patients.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70857_105349
Citations
1
Primary Topic
Metabolomics and Mass Spectrometry Studies
Type
article
Field-Weighted Citation Impact
0.81
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article

Investigating Disparities in Metabolite Concentrations Using Gas Chromatography Mass Spectroscopy Among Patients with Alzheimer's Disease and Healthy Subjects

Raman Singh, Suruchi Chaubey, Pratima Singh
1 citations
Alzheimer s & Dementia
Metabolomics and Mass Spectrometry Studies
0.81
article

Investigating Disparities in Metabolite Concentrations Using Gas Chromatography Mass Spectroscopy Among Patients with Alzheimer's Disease and Healthy Subjects

Raman Singh, Suruchi Chaubey, Pratima Singh
article en
1 citations

Abstract

According to our research, Alzheimer's disease is linked to elevated levels of glycine and aspartate and decreased levels of phenylalanine, tyrosine, methionine, and tryptophan. These amino acid disturbances are associated with cognitive deterioration, implying that they might be used as biomarkers for Alzheimer's disease diagnosis and treatment. Supplementing with amino acids may be a viable strategy to slow the decline of cognitive function in AD patients.

Alzheimer s & DementiaVol. 21(S3)
Chitkara University (IN)
No poverty
Openalex Percentile: Top 20%
Metabolomics and Mass Spectrometry Studies
0.81
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