Association of Moderate‐to‐Severe Chronic Pain with Cognitive Decline and Alzheimer's Biomarkers in the Alzheimer's Disease Neuroimaging Initiative
Moderate-to-severe chronic pain contributes to accelerated cognitive decline and general neurodegeneration, primarily via Aβ. These findings highlight the need to consider moderate-to-severe chronic pain, rather than just presence/absence of chronic pain in AD risk assessments and interventions.
Authors
- Shelby Hughes (ORCID: https://orcid.org/0000-0002-4351-842X)
- Imanuel Lerman (ORCID: https://orcid.org/0000-0002-6564-7222)
- Tyler Bell (ORCID: https://orcid.org/0000-0001-5702-5995)
- Christine Fennema‐Notestine (ORCID: https://orcid.org/0000-0002-6527-6361)
- Erin E. Sundermann (ORCID: https://orcid.org/0000-0001-5821-8035)
- Jeremy A. Elman (ORCID: https://orcid.org/0000-0002-5840-1769)
- William S. Kremen (ORCID: https://orcid.org/0000-0002-8629-5609)
- Carol E. Franz (ORCID: https://orcid.org/0000-0002-8987-1755)
Institutions
- University of San Diego (US)
- University of California San Diego (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70857_106768
- Primary Topic
- Pain Management and Opioid Use
- Type
- article
- Field-Weighted Citation Impact
- 0.00