Amyloid accumulation within emotional regulation areas associated with PTSD symptomatology in cognitively unimpaired older adults 1,5 years after the Covid‐19 pandemic
Our findings suggest that a faster rate of early Aβ accumulation in brain regions linked to emotional processing may heighten vulnerability to stress-related symptoms. The association with intrusion symptoms across multiple regions underscores the role of dynamic changes in Aβ pathology in emotional regulation and rumination. Additionally, women and individuals with pre-existing mental health symptoms appear more vulnerable.
Authors
- Karine Fauria (ORCID: https://orcid.org/0000-0003-1506-4405)
- Eleni Palpatzis (ORCID: https://orcid.org/0000-0001-8478-273X)
- Anna Brugulat‐Serrat (ORCID: https://orcid.org/0000-0001-8988-5658)
- Gonzalo Sánchez‐Benavides
- Muge Akinci
- Juan Domingo Gispert
- Eider M Arenaza‐Urquijo
- Mahnaz Shekari
Institutions
- Universitat Pompeu Fabra (ES)
- Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (ES)
- Pasqual Maragall Foundation (ES)
- Barcelonaβeta Brain Research Center (ES)
- Hospital Del Mar (ES)
- Barcelona Institute for Global Health (ES)
- Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (ES)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70857_105045
- Primary Topic
- Posttraumatic Stress Disorder Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00