Restoring cell‐cell communication networks to enhance cognition and reduce inflammation in Alzheimer’s disease

Astrocyte-to-neuron conversion reverses several AD-associated signaling pathways, which may be part of the underlying mechanism for its beneficial effects on cognition and neuroinflammation. This work not only elucidates some of the cascading molecular effects of astrocyte-to-neuron conversion but also highlights pathways that can be directly enhanced or inhibited to potentiate protective or regenerative effects.