High <i>p</i> ‐Tau217 Levels Nullify Age‐related Cognitive Protection in Younger Older Adults
Our results indicate that high p-tau217 levels negate the protective effect of youth on cognitive decline, highlighting the importance of assessing p-tau217 in younger older adult populations to enable early interventions for Alzheimer's Disease.
Authors
- Julia Kofler (ORCID: https://orcid.org/0000-0003-4298-7328)
- Dana Tudorascu (ORCID: https://orcid.org/0000-0003-4675-3692)
- Tharick Ali Pascoal (ORCID: https://orcid.org/0000-0001-9057-8014)
- Xuemei Zeng (ORCID: https://orcid.org/0000-0002-6561-5079)
- Miloš D. Ikonomović (ORCID: https://orcid.org/0000-0002-8745-3293)
- Sarah Berman (ORCID: https://orcid.org/0000-0002-5096-4962)
- Marissa F. Farinas (ORCID: https://orcid.org/0000-0002-3889-2185)
- Beth E. Snitz (ORCID: https://orcid.org/0000-0002-9978-1374)
- Alexandra Gogola (ORCID: https://orcid.org/0000-0002-8798-1715)
- Margaret A Bedison
- Cristy Matan
- Rebecca A. Deek (ORCID: https://orcid.org/0000-0002-8783-4694)
- Robert A. Sweet (ORCID: https://orcid.org/0000-0001-9154-9709)
- Jeremy Gu
- Tara K Lafferty
- Jennifer H Lingler
- Lamia Choity
- Ann D Cohen
- C. Elizabeth Shaaban
- Michel N Nafash
- Thomas K Karikari
- Oscar L Lopez
- William E Klunk
- Rocco B Mercurio
- M. Ilyas Kamboh
- Victor L Villemagne
Institutions
- University of Pittsburgh (US)
- Alzheimer’s Disease Neuroimaging Initiative (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_103605
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00