Preclinical Study on Sabin Strain-Based DTaP-sIPV/Hib Pentavalent Vaccine: Evaluation of Repeated-Dose Toxicity and Immunogenicity
The DTacP-sIPV/Hib vaccine exhibits a favorable safety profile and robust immunogenicity in rats, supporting its further clinical development. The use of Sabin strains reduces biosafety risks and manufacturing costs, making this vaccine a promising candidate for immunization programs, especially in resource-limited regions.
Authors
- H Zheng
- Han Chu
- Ping Lü (ORCID: https://orcid.org/0009-0006-6008-6469)
- Jiana Wen
- Wenzhu Hu
- Lujie Yang (ORCID: https://orcid.org/0000-0003-0013-0529)
- Shengjie Ouyang
- Jiangli Liang
- Qin Xinhua
- LuKui Cai
- Qin Gu (ORCID: https://orcid.org/0000-0002-3722-6375)
- Mingqing Wang
- Xiaoyu Wang (ORCID: https://orcid.org/0000-0003-2933-7582)
- Na Gao (ORCID: https://orcid.org/0000-0002-2941-1925)
- Guoyang Liao
- Jingyan Li
- Hongwei Liao
- Jingsi Yang
- Yan Ma
- Guang Ji
- Yuting Fu
- Hongbo Chen
- Ting Zhao
- Qiuyan Ji
- Yixian Fu
- Wenlu Kong
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Innovation Team (China) (HK)
Publication Details
- Journal
- Vaccines
- Published
- 2025-12-25
- DOI
- https://doi.org/10.3390/vaccines14010029
- Primary Topic
- Bacterial Infections and Vaccines
- Type
- article
- Field-Weighted Citation Impact
- 0.00