Heritable and measured polygenic influences on Mild Cognitive Impairment (MCI) in the Vietnam Era Twin Study of Aging (VETSA)
Our results suggest that with follow-up into later life and considering stability of diagnosis, heritability for amnestic MCI is on par with heritability estimates for AD, while for general MCI estimates were lower, although confidence intervals overlapped. Despite strong heritability, genetic contributions to amnestic and total MCI are not captured by extant polygenic scores for AD or educational attainment warranting additional follow-up.
Authors
- Christine Fennema‐Notestine (ORCID: https://orcid.org/0000-0002-6527-6361)
- Jeremy A. Elman (ORCID: https://orcid.org/0000-0002-5840-1769)
- Nathan A. Gillespie (ORCID: https://orcid.org/0000-0001-8655-2823)
- Michael J. Lyons (ORCID: https://orcid.org/0000-0001-6516-9219)
- Carol E. Franz (ORCID: https://orcid.org/0000-0002-8987-1755)
- Chandra A Reynolds
- Michael C. Neale
- Matthew S. Panizzon
- William S. Kremen
Institutions
- Virginia Commonwealth University (US)
- University of Colorado Boulder (US)
- University of California San Diego (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70857_104205
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00