Sleep spindles and slow oscillations predict amyloid beta, tau pathology, and cognitive decline in persons with mild to moderate Alzheimer's Disease.”
Our findings demonstrate that spindle and SO activity during sleep constitute predictive and non-invasive biomarkers of neurodegeneration and cognition in AD patients and novel treatment targets for delaying cognitive decline and AD progression.
Authors
- Ferrán Barbé (ORCID: https://orcid.org/0000-0002-2340-8928)
- Shahla Bakian Dogaheh
- Anna Carnes
- Farida Dakterzada
- Thien Thanh Dang‐Vu
- Gerard Piñol‐Ripoll
- Arsenio Paez
- Sam O Gillman
Institutions
- University of Oxford (GB)
- Hospital Universitari de Santa Maria (ES)
- Institut Universitaire de Gériatrie de Montréal (CA)
- Instituto de Investigación Biomédica de Lleida (ES)
- Concordia University (CA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_104172
- Primary Topic
- Sleep and Wakefulness Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00