Associations between plasma pTau217, cognitive impairment, and synaptic density in AD vulnerable brain regions
The unexpected directional relationship between pTau217 and synaptic density in the medial temporal lobe could be due to an early compensatory response to pathology accumulation since most individuals in this sample were cognitively unimpaired. Longitudinal studies are forthcoming to determine the trajectory of plasma pTau217 and synaptic density.
Authors
- Randall S. Johnson (ORCID: https://orcid.org/0000-0002-4084-6639)
- Tobey J. Betthauser (ORCID: https://orcid.org/0000-0001-8856-1352)
- Todd E. Barnhart (ORCID: https://orcid.org/0000-0002-9981-2150)
- Erin M. Jonaitis (ORCID: https://orcid.org/0009-0004-5091-8255)
- Rachael E. Wilson (ORCID: https://orcid.org/0000-0003-4197-7777)
- Yazan Hammad (ORCID: https://orcid.org/0000-0002-0394-5654)
- Alexandra H DiFilippo (ORCID: https://orcid.org/0000-0003-0003-8968)
- Mary‐Elizabeth Pasquesi
- Kao Lee Yang
- Bradley T Christian
- Jonathan Engle
- Henrik Zetterberg
- Yue Ma
- Nicholas Ashton
- Barbara B. Bendlin
Institutions
- University of Wisconsin–Madison (US)
- Hong Kong Science and Technology Parks Corporation (HK)
- Geriatric Research Education and Clinical Center (US)
- UK Dementia Research Institute (GB)
- University of Wisconsin Health (US)
- William S. Middleton Memorial Veterans Hospital (US)
- Wisconsin Division of Public Health (US)
- National Hospital for Neurology and Neurosurgery (GB)
- University College London (GB)
- University of Gothenburg (SE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_103318
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00