Longitudinal Multimodal Imaging of Leptovitelliform Maculopathy

<b>Purpose:</b> To present longitudinal, multimodal imaging findings of leptovitelliform maculopathy, an underrecognized condition within the spectrum of adult vitelliform lesions. <b>Methods:</b> A single case was evaluated over 5 years. <b>Results:</b> A 70-year-old man presented with vitelliform lesions accompanied by subretinal drusenoid deposits/reticular pseudodrusen and a thin choroid (leptochoroid). Multimodal imaging demonstrated progressive collapse of the vitelliform lesions, followed by extensive and worsening outer retinal atrophy. <b>Conclusions:</b> Leptovitelliform maculopathy may demonstrate progressive collapse of vitelliform lesions, ultimately leading to significant outer retinal atrophy. Longitudinal multimodal imaging is valuable in characterizing this aggressive and underrecognized disease entity.