Longitudinal Analysis of Brain Entropy Changes in Alzheimer's Disease

Elevated whole-brain BEN is associated with higher AD risk, aligning with prior studies linking increased entropy to neuropathological changes like amyloid and tau deposition. However, elevated BEN in specific ROIs, such as Frontal_Sup_Left and hippocampi, may reflect enhanced cognitive adaptability and reduced AD risk. This resilience may result from greater neural variability and complexity, particularly in the hippocampus, where heightened entropy supports memory and consciousness. These findings highlight the dual role of BEN, where global increases suggest AD progression, while region-specific elevations may indicate protective neural mechanisms.