Imaging age‐related hippocampal connectivity changes across the adult lifespan in a large‐scale dataset

This study revealed age-related degeneration in key hippocampal pathways, evidenced by reduced FA, supporting previous volumetric and perfusion findings of hippocampus. Notably, the increased fiber density pathways connecting the hippocampus to the prefrontal cortex may suggest a compensatory mechanism, but this requires further validation. These findings may offer insights into early age-related axonal and microstructural alterations underlying macroscale hippocampal changes in later life. Figure 1. Workflow of key hippocampal pathways tractography. Figure 2. Group-level representation of hippocampal pathways in young and old groups. Figure 3. Correlation analysis between hippocampal pathway measurements and age.