Mesial temporal tau pathology impacts basal forebrain degeneration in early Alzheimer's disease
Early-stage tau pathology in the mesial-temporal (MTL) region was assessed using <sup>18</sup>F-MK6240 positron emission tomography. Co-occurring amyloid beta and MTL tau was linked to reduced nucleus basalis of Meynert (Ch4) volume in cognitively unimpaired individuals. Ch4 volume was associated with MTL tau burden exclusively in preclinical Alzheimer's disease (AD). No comparable association was observed between MTL tau and hippocampal volume. The MTL tau-Ch4 association persisted into the prodromal stage of AD.
Authors
- Vincent Doré (ORCID: https://orcid.org/0000-0002-8051-0558)
- Paul Maruff (ORCID: https://orcid.org/0000-0002-6947-9537)
- Natasha Krishnadas (ORCID: https://orcid.org/0000-0002-5374-2839)
- Matthew Dean
- Christopher C. Rowe
- Colin L. Masters
- Elizabeth J. Coulson
- Ying Xia
- Pierrick Bourgeat
- Jurgen Fripp
- Victor L. Villemagne
Institutions
- The University of Queensland (AU)
- The University of Melbourne (AU)
- University of Pittsburgh (US)
- Florey Institute of Neuroscience and Mental Health (AU)
- Australian e-Health Research Centre (AU)
- CSIRO Health and Biosecurity (AU)
- Austin Health (AU)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz.71050
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Alzheimer's Association
- Science and Industry Endowment Fund
- Commonwealth Scientific and Industrial Research Organisation
- Edith Cowan University
- Dementia Collaborative Research Centres, Australia
- State Government of Victoria
- Australian Alzheimer's Research Foundation
- Medical Research Council
- National Health and Medical Research Council