Integrated serum metabolomics reveal molecular mechanism of Xietu Hemu prescription on metabolic dysfunction-associated steatotic liver disease-related obesity

XHP effectively inhibits adipogenesis and enhances lipid metabolism homeostasis through the LEP/AMPK/PPARγ pathway, presenting a promising multi-target therapeutic strategy for MASLD by mitigating lipotoxicity.

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Publication Details

Journal
World Journal of Hepatology
Published
2025-12-26
DOI
https://doi.org/10.4254/wjh.v17.i12.113660
Primary Topic
Liver Disease Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

Integrated serum metabolomics reveal molecular mechanism of Xietu Hemu prescription on metabolic dysfunction-associated steatotic liver disease-related obesity

Tian-su Lv, Yixian He, Yi-Fan Lu, Wei Wei et al.
World Journal of Hepatology
Liver Disease Diagnosis and Treatment
article

Integrated serum metabolomics reveal molecular mechanism of Xietu Hemu prescription on metabolic dysfunction-associated steatotic liver disease-related obesity

Tian-su Lv, Yixian He, Yi-Fan Lu, Wei Wei, Yi Wei, Zhe Cheng, Yi-Xuan Xie, Yan Lou, Xi-Qiao Zhou, Jiang-Yi Yu
article en

Abstract

XHP effectively inhibits adipogenesis and enhances lipid metabolism homeostasis through the LEP/AMPK/PPARγ pathway, presenting a promising multi-target therapeutic strategy for MASLD by mitigating lipotoxicity.

World Journal of HepatologyVol. 17(12)
Nanjing University of Chinese Medicine (CN)
Good health and well-being
Openalex Percentile: Top 30%
Liver Disease Diagnosis and Treatment
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Integrated serum metabolomics reveal molecular mechanism of Xietu Hemu prescription on metabolic dysfunction-associated steatotic liver disease-related obesity — Tian-su Lv, Yixian He, et al. · World Journal of Hepatology (2025) | TGRS Research Map | TGRS