Integrated serum metabolomics reveal molecular mechanism of Xietu Hemu prescription on metabolic dysfunction-associated steatotic liver disease-related obesity
XHP effectively inhibits adipogenesis and enhances lipid metabolism homeostasis through the LEP/AMPK/PPARγ pathway, presenting a promising multi-target therapeutic strategy for MASLD by mitigating lipotoxicity.
Authors
- Tian-su Lv
- Yixian He
- Yi-Fan Lu
- Wei Wei
- Yi Wei
- Zhe Cheng
- Yi-Xuan Xie
- Yan Lou
- Xi-Qiao Zhou
- Jiang-Yi Yu
Institutions
- Nanjing University of Chinese Medicine (CN)
Publication Details
- Journal
- World Journal of Hepatology
- Published
- 2025-12-26
- DOI
- https://doi.org/10.4254/wjh.v17.i12.113660
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00