Structural similarity networks reveal brain vulnerability in dementia
MIND networks were systematically integrated with normative modeling in AD. Negative deviations stratify clinical stages and correlate with neuropathology. Negative deviation count distinguishes APOE genotypes, highest in ε4 homozygotes. Deviations align with neurotransmitter maps. Individual brain maps enable precision medicine approaches in dementia.
Authors
- Amir Ebneabbasi (ORCID: https://orcid.org/0000-0001-9348-5702)
- Jakob Seidlitz (ORCID: https://orcid.org/0000-0002-8164-7476)
- Marcella Montagnese (ORCID: https://orcid.org/0000-0001-5467-0104)
- Sarah E. Morgan (ORCID: https://orcid.org/0000-0002-1261-5884)
- Richard A. I. Bethlehem (ORCID: https://orcid.org/0000-0002-0714-0685)
- James H. Cole
- Clara Pecci‐Terroba
- Rafael Romero‐García
- Timothy Rittman
- Natalia García‐San‐Martín
Institutions
- Children's Hospital of Philadelphia (US)
- King's College London (GB)
- MRC Cognition and Brain Sciences Unit (GB)
- Hawassa University (ET)
- University of Cambridge (GB)
- Brain Mapping Foundation (US)
- Translational Therapeutics (United States) (US)
- UK Dementia Research Institute (GB)
- Instituto de Biomedicina de Sevilla (ES)
- National Hospital for Neurology and Neurosurgery (GB)
- Lifespan (US)
- University College London (GB)
- Universidad de Sevilla (ES)
- University of Pennsylvania (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz.70973
- Citations
- 2
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.86
Funders
- National Institute for Health and Care Research
- Department of Health and Social Care
- National Institutes of Health
- Medical Research Council
- NIHR Cambridge Biomedical Research Centre
- National Institute on Aging