Development of small molecules promoting tau degradation in Alzheimer disease

The development of small-molecule PROTACs may bring breakthrough medicines for AD and other neurodegenerative diseases.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70859_106337
Primary Topic
Protein Degradation and Inhibitors
Type
article
Field-Weighted Citation Impact
0.00
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Development of small molecules promoting tau degradation in Alzheimer disease

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Alzheimer s & Dementia
Protein Degradation and Inhibitors
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Development of small molecules promoting tau degradation in Alzheimer disease

Thomai Mouskeftara, Sophia Schedin Weiss, Lisha Wang, Bengt Winblad Winblad, Lars O Tjernberg, Banesh Sooram, Rajnish Kumar
article en

Abstract

The development of small-molecule PROTACs may bring breakthrough medicines for AD and other neurodegenerative diseases.

Alzheimer s & DementiaVol. 21(S5)
Karolinska University Hospital (SE), Karolinska Institutet (SE), Indian Institute of Technology BHU (IN)
Openalex Percentile: Top 36%
Protein Degradation and Inhibitors
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