Blood markers of the renin‐angiotensin system and cognitive impairment: The Look AHEAD Study
In this sample of older adults with T2DM and dementia-free at baseline, we found increased ACE-2 enzyme over time. We further found lower levels of some of the enzymes in those of non-white race and those with cognitive impairment. ACE-2 enzyme is involved in the production of ANG1-7; thus, the findings of increased ACE-2 activity associated with increased ACE1-7 levels are biologically plausible. These findings warrant further evaluation.
Authors
- Patrick G. Kehoe (ORCID: https://orcid.org/0000-0002-7542-1139)
- Michelle C. Carlson (ORCID: https://orcid.org/0000-0003-2465-7421)
- Kathleen Hayden
- Daniel J. Asby (ORCID: https://orcid.org/0000-0002-1219-8347)
- Mark A. Espeland (ORCID: https://orcid.org/0000-0002-3711-1949)
- Jeanne M. Clark (ORCID: https://orcid.org/0000-0003-1194-0092)
- J. Scott Miners (ORCID: https://orcid.org/0000-0001-8594-1640)
- Andrea Anderson (ORCID: https://orcid.org/0000-0002-8328-9166)
- Sevil Yasar
- Owen T. Carmichael
Institutions
- Rutgers, The State University of New Jersey (US)
- Pennington Biomedical Research Center (US)
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- Johnson University (US)
- University of Bristol (GB)
- Wake Forest University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_104503
- Primary Topic
- Renin-Angiotensin System Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00