Maternal Folic Acid Supplementation Ameliorates Outflow Tract Malformations in <i>Tbx1</i> Hypomorphic Mice via Notch and Midkine Signaling
Maternal FA supplementation improved cardiac OFT malformations in Tbx1<sup>neo/neo</sup> embryos by enhancing NCC migration and fate specification, possibly mediated by Notch and Midkine signaling activation. Our findings provide mechanistic insights into the observed reduction in congenital heart defects with FA and suggest its potential as a minimally invasive prenatal intervention.
Authors
- K. Uchida
- Shinsuke Shibata (ORCID: https://orcid.org/0000-0002-1185-9043)
- Takahisa UCHIDA
- Hiroyuki Yamagishi (ORCID: https://orcid.org/0000-0002-9756-3744)
- Kazuki Yamamoto
- Takatoshi Tsuchihashi
- Kazuki Kodo
- Manabu Shirai
Institutions
- Tokyo Medical University (JP)
- Keio University (JP)
- Tokyo Metropolitan Ohtsuka Hospital (JP)
- National Cerebral and Cardiovascular Center (JP)
- Kawasaki Municipal Hospital (JP)
- Tokyo Metropolitan Children's Medical Center (JP)
- Niigata University (JP)
Publication Details
- Journal
- Circulation Journal
- Published
- 2025-12-25
- DOI
- https://doi.org/10.1253/circj.cj-25-0958
- Primary Topic
- Folate and B Vitamins Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Keio University
- Japan Society for the Promotion of Science