Evaluating Scoring and Weighting Methods of Global Cognition in a Harmonized United States and Korean Research Sample
Regardless of scoring method, global cognitive composites were similarly related to validity indicators of cognition/functioning and structural neuroimaging in a harmonized sample. MMSE<sub>Composite</sub> showed the strongest relationships with CDR but was less strongly associated with frontal lobe volume. Composites demonstrated stronger relationships with structural neuroimaging compared to standalone measures. Future work aims to evaluate similarities and differences between cohorts and evaluate relationships longitudinally.
Authors
- Evgeny J. Chumin (ORCID: https://orcid.org/0000-0001-6696-6105)
- Timothy J. Hohman (ORCID: https://orcid.org/0000-0002-3377-7014)
- Adam M. Staffaroni (ORCID: https://orcid.org/0000-0002-3903-9805)
- Min Soo Byun (ORCID: https://orcid.org/0000-0003-3159-4510)
- Leslie S. Gaynor (ORCID: https://orcid.org/0000-0003-1121-4365)
- Meichen Yu (ORCID: https://orcid.org/0009-0009-2228-1417)
- Andrew Joel Saykin
- Joshua Garcia
- Kwangsik Nho
- Dahyun Yi
- Luis D. Medina
- Dong Young Lee
- Paul K Crane
- Shannon L Risacher
Institutions
- Seoul National University (KR)
- University of California, San Francisco (US)
- University of Washington (US)
- Seoul National University Hospital (KR)
- University Memory and Aging Center (US)
- Indiana University School of Medicine
- University of Houston (US)
- Indiana University – Purdue University Indianapolis (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70857_107728
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00