Tri-modal assessment reveals early visual pathway degeneration in patients with MSA-C
This large-scale multimodal study provides robust in vivo evidence that MSA-C involves early retinal neurodegeneration, functional conduction delay, and central white matter degeneration. The convergence of OCT, VEP, and DTI parameters suggests bidirectional retinocortical degeneration. Our findings support the potential of these parameters for early detection and highlight the visual pathway as a promising potential biomarker in synucleinopathies.
Authors
- Chunrong Wang (ORCID: https://orcid.org/0000-0002-1724-3426)
- Long Qin (ORCID: https://orcid.org/0000-0001-9995-7176)
- Huirong Peng
- Daji Chen
- Mengyuan Dong (ORCID: https://orcid.org/0000-0003-1602-3154)
- Xuan Hou (ORCID: https://orcid.org/0009-0002-8874-4794)
- Riwei Ouyang
- Beisha Tang
- Jiawei He
- Zhe Long
- Linliu Peng
- Zhao Chen
- Hong Jiang
- Yuting Shi
- Rong Qiu
- Qi Wu
- Feiyan Deng
- Lang He
- Linlin Wan
Institutions
- Central South University (CN)
- Second Xiangya Hospital of Central South University (CN)
- Third Xiangya Hospital (CN)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- Neurobiology of Disease
- Published
- 2025-12-25
- DOI
- https://doi.org/10.1016/j.nbd.2025.107243
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00