C7-Sulfonamide functionalization of 7-deazaadenosines: sangivamycin analogues with Haspin inhibitory activity
We report a robust method for C7-sulfonamide installation on 7-deazaadenosines, enabled by an unprecedentedly stable sulfonyl chloride. This general transformation introduces a new functionalization site and expands nucleoside chemical space, offering a powerful platform for constructing tailored probes and analogues in synthetic and bioorganic chemistry.
Authors
- Radim Nencka (ORCID: https://orcid.org/0000-0001-6167-0380)
- Milan Dejmek (ORCID: https://orcid.org/0000-0002-8195-971X)
- Michal Šála (ORCID: https://orcid.org/0000-0003-1554-6906)
- Milan Štefek
Institutions
- Charles University (CZ)
- Czech Academy of Sciences, Institute of Organic Chemistry and Biochemistry (CZ)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-12-26
- DOI
- https://doi.org/10.1039/d5cc06746d
- Primary Topic
- Cyclopropane Reaction Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission
- Akademie Věd České Republiky