Diagnostic performance of plasma biomarkers for detecting amyloid co‐pathology in Neuronal α‐Synuclein Disease
Plasma pTau217 (individually and combined with other biomarkers) accurately detects Aβ in αSyn+ participants. These findings highlight potential for using plasma pTau217 as a tool for Aβ screening and stratification in clinical trials for alpha-synucleinopathies such as dementia with Lewy bodies and Parkinson's disease.
Authors
- Carla Abdelnour (ORCID: https://orcid.org/0000-0002-7636-9758)
- Geoffrey A. Kerchner (ORCID: https://orcid.org/0000-0001-7674-0695)
- A. Gordon Smith (ORCID: https://orcid.org/0009-0008-7909-9395)
- Katrin I. Andreasson (ORCID: https://orcid.org/0000-0001-8391-4155)
- Veronica Ramirez (ORCID: https://orcid.org/0000-0001-5083-196X)
- Sara A. Lorkiewicz (ORCID: https://orcid.org/0000-0002-0560-5979)
- Burak Arslan (ORCID: https://orcid.org/0000-0001-7229-3226)
- Melanie J. Plastini (ORCID: https://orcid.org/0000-0003-2011-7882)
- Kathleen L. Poston (ORCID: https://orcid.org/0000-0003-3424-7143)
- Laia Montoliu‐Gaya (ORCID: https://orcid.org/0000-0001-7684-6318)
- Joseph R. Winer (ORCID: https://orcid.org/0000-0003-4069-3158)
- Elizabeth C. Mormino (ORCID: https://orcid.org/0000-0002-4542-6537)
- Tianyu Pan (ORCID: https://orcid.org/0000-0003-2089-2280)
- Christina B. Young (ORCID: https://orcid.org/0000-0001-9535-2137)
- Hillary Vossler
- Ted N. Wilson
- Lu Tian
- Victor W. Henderson
- Nicholas Ashton
- Thomas J. Montine
- Marian Shahid
- Henrik Zetterberg
Institutions
- Roche (Switzerland) (CH)
- King's College London (GB)
- Sahlgrenska University Hospital (SE)
- UK Dementia Research Institute (GB)
- University College London (GB)
- University of Gothenburg (SE)
- Stanford University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_104596
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00