P53 Expression Associated With Smoking for Laryngeal Tumor Recurrence in Patients With Free Surgical Margins

A prospective, consecutive patient cohort study was performed in a public tertiary university hospital from January/2015-18, to define whether p53 gene expression is a risk factor for tumor recurrence, disease-free survival, and overall survival. Four patients had a tumor recurrence, and three were at p53 level C. The survival of p53-positive patients was lower when compared with those with negative expression (<i>p</i> = 0.039). The predictor of laryngeal tumor recurrence was strong p53 gene expression associated with smoking increasing by 21 times the chance of laryngeal tumor recurrence, reinforcing the importance of p53 as a marker during follow-up.