Clustering Cognitive Decline Trajectories in Mild Alzheimer’s Dementia: Insights from the EXPEDITION3 Trial

Longitudinal cognitive and functional measurements can effectively identify more homogeneous groups among individuals with mild dementia due to AD. These identified groups differ in both baseline and longitudinal progression characteristics, providing insights to the heterogeneity of AD progression. Notably, clusters with similar baseline scores (e.g., Cluster 1 and Cluster 3) displayed markedly different trajectories, highlighting the need to consider longitudinal patterns to inform personalized treatment strategies and to facilitate enrichment designs in future AD clinical trial designs.