Heterocyclic Quinoline Derivatives as Innovative Neuroprotective Agents for Alzheimer's Disease
The designed heterocyclic-based derivative showed physicochemical characteristics compatible with oral use and passage through BBB and relevant antioxidant and anti-inflammatory effects. These findings suggest these compounds are promising multitarget agents for preventing AD, offering opportunities for future drug design in this field.
Authors
- Aline Rigon Zimmer (ORCID: https://orcid.org/0000-0002-8309-7068)
- Karine Rigon Zimmer (ORCID: https://orcid.org/0000-0002-7962-7353)
- Saulo Fernandes de Andrade (ORCID: https://orcid.org/0000-0003-2873-7939)
- Angélica Rocha Joaquim (ORCID: https://orcid.org/0000-0002-9322-7794)
- Maria Paula Faccin Huth
- Marcela Silva Lopes
Institutions
- Universidade Federal do Rio Grande do Sul (BR)
- Universidade Federal de Ciências da Saúde de Porto Alegre (BR)
- Universidade Federal de Santa Maria (BR)
- McGill University (CA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70859_104682
- Primary Topic
- Cholinesterase and Neurodegenerative Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00