Impact of baseline amyloid and depressive symptom trajectory on longitudinal digital clock scores in community dwelling older adults

In a cohort of CN older adults, individuals with higher baseline cortical amyloid burden and worsening depressive symptoms showed steeper declines on the DCT. These results suggest that individuals with greater/worsening depressive symptoms in the context of elevated cortical amyloid burden may be particularly vulnerable to cognitive decline (even in preclinical stages) on sensitive, easy-to-administer measures such as the DCT, similar to prior work examining cognitive testing composite scores. Findings highlight the clinical importance of monitoring emerging mood disturbances in older adults. Future work will examine how these relationships relate to clinical progression.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70857_104690
Primary Topic
Dementia and Cognitive Impairment Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Impact of baseline amyloid and depressive symptom trajectory on longitudinal digital clock scores in community dwelling older adults

Rachel F. Buckley, Bernard Hanseeuw, Jennifer R. Gatchel, Jessie Fanglu Fu et al.
Alzheimer s & Dementia
Dementia and Cognitive Impairment Research
article

Impact of baseline amyloid and depressive symptom trajectory on longitudinal digital clock scores in community dwelling older adults

Rachel F. Buckley, Bernard Hanseeuw, Jennifer R. Gatchel, Jessie Fanglu Fu, Yakeel T. Quiroz, Talia L. Robinson, Patrizia Vannini, Gad Marshall, Rebecca England Amariglio, M. Farrell, Abigail LaCasse, Catherine E Munro, Natalie R Scher, Deborah Blacker, Keith A. Johnson, Dorene M. Rentz, Reisa A. Sperling, Michael J. Properzi
article en

Abstract

In a cohort of CN older adults, individuals with higher baseline cortical amyloid burden and worsening depressive symptoms showed steeper declines on the DCT. These results suggest that individuals with greater/worsening depressive symptoms in the context of elevated cortical amyloid burden may be particularly vulnerable to cognitive decline (even in preclinical stages) on sensitive, easy-to-administer measures such as the DCT, similar to prior work examining cognitive testing composite scores. Findings highlight the clinical importance of monitoring emerging mood disturbances in older adults. Future work will examine how these relationships relate to clinical progression.

Alzheimer s & DementiaVol. 21(S3)
Boston University (US), Brigham and Women's Hospital (US), Harvard University (US), William James College (US), McLean Hospital (US), Universidad de Antioquia (CO), Massachusetts General Hospital (US), Athinoula A. Martinos Center for Biomedical Imaging (US), UCLouvain (BE)
Reduced inequalities
Openalex Percentile: Top 33%
Dementia and Cognitive Impairment Research
DOIOpen Access PDFOpenAlex
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