Neuroimaging correlates and prognostic utility of accelerated long‐term forgetting in presymptomatic autosomal dominant Alzheimer's disease

Our results suggest that ALF in presymptomatic ADAD is related to early focal structural changes in the PFC, but not the MTL. Follow-up demonstrated that ALF severity is not only associated with the presence of AD pathology but also is predictive of clinical onset, identifying those at highest risk of imminent decline. ALF testing is a biologically relevant measure that offers promise in aiding presymptomatic trial recruitment, as a presymptomatic cognitive endpoint, and potentially as a screening tool in the wider population.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70857_105700
Primary Topic
Dementia and Cognitive Impairment Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Neuroimaging correlates and prognostic utility of accelerated long‐term forgetting in presymptomatic autosomal dominant Alzheimer's disease

Rachana Tank, Helen Rice, Philip SJ. Weston, Kirsty Lu et al.
Alzheimer s & Dementia
Dementia and Cognitive Impairment Research
article

Neuroimaging correlates and prognostic utility of accelerated long‐term forgetting in presymptomatic autosomal dominant Alzheimer's disease

Rachana Tank, Helen Rice, Philip SJ. Weston, Kirsty Lu, Duncan Alston, Nicholas Magill, Damien Ferguson, Art O'connor, Chloe Young, Christopher S Parker, Sebastian J Crutch, Ian B. Malone, Nick C Fox
article en

Abstract

Our results suggest that ALF in presymptomatic ADAD is related to early focal structural changes in the PFC, but not the MTL. Follow-up demonstrated that ALF severity is not only associated with the presence of AD pathology but also is predictive of clinical onset, identifying those at highest risk of imminent decline. ALF testing is a biologically relevant measure that offers promise in aiding presymptomatic trial recruitment, as a presymptomatic cognitive endpoint, and potentially as a screening tool in the wider population.

Alzheimer s & DementiaVol. 21(S3)
University of London (GB), London School of Hygiene & Tropical Medicine (GB), UK Dementia Research Institute (GB), NIHR Queen Square Dementia Biomedical Research Unit (GB), The London College (GB), National Hospital for Neurology and Neurosurgery (GB), University College London (GB)
Openalex Percentile: Top 33%
Dementia and Cognitive Impairment Research
DOIOpen Access PDFOpenAlex
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Neuroimaging correlates and prognostic utility of accelerated long‐term forgetting in presymptomatic autosomal dominant Alzheimer's disease — Rachana Tank, Helen Rice, et al. · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS