CT-Based Quantification of Prostate Volume Change After LHRH-Agonist Androgen Deprivation: A Prospective, Three-Reader Study for Radiotherapy Planning

Short-course LHRHa induced consistent CT-measured cytoreduction, with more than half of cases achieving ≥15% shrinkage within 8 weeks. Prostate downsizing was reproducible across readers and accompanied by marked PSA and testosterone declines, although biochemical responses did not predict volumetric change. These findings support incorporating a short neoadjuvant "window" before RT simulation and highlight the need for larger studies to refine predictors and compare agonist vs. antagonist trajectories.

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Publication Details

Journal
Life
Published
2025-12-25
DOI
https://doi.org/10.3390/life16010029
Primary Topic
Prostate Cancer Diagnosis and Treatment
Type
article
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article

CT-Based Quantification of Prostate Volume Change After LHRH-Agonist Androgen Deprivation: A Prospective, Three-Reader Study for Radiotherapy Planning

Jesús Muñoz-Rodríguez, Meritxell Pérez Márquez, M. Galdeano Rubio, N. Feltes et al.
Life
Prostate Cancer Diagnosis and Treatment
article

CT-Based Quantification of Prostate Volume Change After LHRH-Agonist Androgen Deprivation: A Prospective, Three-Reader Study for Radiotherapy Planning

Jesús Muñoz-Rodríguez, Meritxell Pérez Márquez, M. Galdeano Rubio, N. Feltes, Josep Maria Sole Monne, A. Palau Domínguez, Felipe Couñago, S. Pozo, Saturio Paredes-Rubio, Inma Díaz-Álvarez
article en

Abstract

Short-course LHRHa induced consistent CT-measured cytoreduction, with more than half of cases achieving ≥15% shrinkage within 8 weeks. Prostate downsizing was reproducible across readers and accompanied by marked PSA and testosterone declines, although biochemical responses did not predict volumetric change. These findings support incorporating a short neoadjuvant "window" before RT simulation and highlight the need for larger studies to refine predictors and compare agonist vs. antagonist trajectories.

LifeVol. 16(1)
Universitat Autònoma de Barcelona (ES), Hospital Universitario La Paz (ES), Universitat Internacional de Catalunya (ES), Hospital Terrassa (ES), Hospital Universitario HM Madrid (ES), Institute of Research and Innovation Parc Tauli (ES), Universidad Europea de Madrid (ES)
Openalex Percentile: Top 28%
Prostate Cancer Diagnosis and Treatment
DOIOpen Access PDFOpenAlex
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CT-Based Quantification of Prostate Volume Change After LHRH-Agonist Androgen Deprivation: A Prospective, Three-Reader Study for Radiotherapy Planning — Jesús Muñoz-Rodríguez, Meritxell Pérez Márquez, et al. · Life (2025) | TGRS Research Map | TGRS