Estimating clinical transitions in patients with Alzheimer's using Instrumental Activities of Daily Living (IADL)
Functional deterioration appeared to progress to severe stage within 9 years for AD and within 13 years for MCI. Polynomial growth curves may tend to skew transition times at more advanced stages; however, trajectory estimations provide an alternative measure of disease progression with IADL, a broadly used assessment in clinical practice, to assess functional decline corresponding to cognitive deterioration.
Authors
- Q. Zhang
- Amir Abbas Tahami Monfared (ORCID: https://orcid.org/0000-0003-4003-3192)
- Peter J. Morin
- Joel I. Reisman (ORCID: https://orcid.org/0000-0002-0552-161X)
- Dan R. Berlowitz (ORCID: https://orcid.org/0000-0002-8783-5611)
- Ying Wang (ORCID: https://orcid.org/0009-0005-3616-5290)
- Brant S. Mittler
- Weiming Xia
- Raymond Zhang
Institutions
- Boston University (US)
- University of Massachusetts Lowell (US)
- Wentworth Institute of Technology (US)
- Geriatric Research Education and Clinical Center (US)
- South Texas Veterans Health Care System (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70857_107058
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00