Features that Influence Fast Disease Progression in Behavioral Variant Frontotemporal Dementia
Impaired memory, impaired working memory, compulsive behaviors, and irritability were the strongest features of faster progression, and these features more effectively distinguished fast progressors from slow progressors than demographic and clinical variables alone. These findings could help guide early intervention strategies and enhance disease management, by highlighting key symptoms to target, supporting family education, and identifying fast progressors who may benefit from more urgent interventions.
Authors
- Molly Split
- Daliah Ross (ORCID: https://orcid.org/0000-0002-0577-7578)
- Zachary J. Kunicki (ORCID: https://orcid.org/0000-0002-3466-7589)
- Rachel Keszycki (ORCID: https://orcid.org/0000-0001-7686-2959)
- Sarah Prieto (ORCID: https://orcid.org/0000-0001-5697-3010)
- Masood Manoochehri (ORCID: https://orcid.org/0000-0001-5818-180X)
- Edward D. Huey (ORCID: https://orcid.org/0000-0002-8295-5884)
- Megan S Barker
- ARTFL‐LEFFTDS (ALLFTD)
Institutions
- Northwestern University (US)
- Providence College (US)
- Brown University (US)
- Butler Hospital (US)
- Left Hand Design (United States) (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70857_104587
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00