Associations of cognitive debt and cognitive reserve with mixed brain pathology and cognition
Brain pathologies were linked to lower cognitive performance. Cognitive reserve, but not cognitive debt, was independently associated with better cognitive performance (1). There were no significant associations of cognitive debt and cognitive reserve with brain pathologies. The findings suggest that cognitive reserve may influence resilience through mechanisms independent of brain pathology (2). Future longitudinal studies are needed to investigate these pathways and clarify causal relationships. References 1. Vemuri P, Weigand SD, Przybelski SA, Knopman DS, Smith GE, Trojanowski JQ, et al. Cognitive reserve and Alzheimer's disease biomarkers are independent determinants of cognition. Brain. 2011;134(Pt 5):1479-92. 2. Vemuri P, Lesnick TG, Przybelski SA, Knopman DS, Roberts RO, Lowe VJ, et al. Effect of lifestyle activities on Alzheimer disease biomarkers and cognition. Ann Neurol. 2012;72(5):730-8.
Authors
- Anja Schneider (ORCID: https://orcid.org/0000-0002-3377-5828)
- René Mauer (ORCID: https://orcid.org/0000-0002-2204-8895)
- Robert Perneczky (ORCID: https://orcid.org/0000-0003-1981-7435)
- Natalie L. Marchant (ORCID: https://orcid.org/0000-0003-0669-6910)
- Annika Spottke (ORCID: https://orcid.org/0000-0001-9854-2972)
- Gabriel Ziegler (ORCID: https://orcid.org/0000-0001-6589-6416)
- Christoph Laske (ORCID: https://orcid.org/0009-0009-3434-936X)
- Sandra Roeske (ORCID: https://orcid.org/0000-0002-8262-4356)
- Luca Kleineidam (ORCID: https://orcid.org/0009-0006-3309-6856)
- Miranka Wirth (ORCID: https://orcid.org/0000-0002-0725-7314)
- Katharina Büerger (ORCID: https://orcid.org/0000-0002-5898-9953)
- Maxie Liebscher (ORCID: https://orcid.org/0009-0000-7625-5673)
- Josef Priller
- Franka Gloeckner
- Frederic Brosseron
- Jens Wiltfang
- Renat Yakupov
- Emrah Düzel
- Frank Jessen
- Olga M. Klimecki
- DELCODE study group
- Stefan J. Teipel
- Hanna Boscheck
- Ylenia D'Elia
- Michael Wagner
- Oliver Peters
Institutions
- University of Bonn (DE)
- University of Cologne (DE)
- University Hospital Bonn (DE)
- German Center for Neurodegenerative Diseases (DE)
- LMU Klinikum (DE)
- Humboldt-Universität zu Berlin (DE)
- Munich Cluster for Systems Neurology (DE)
- Institut des Sciences Cognitives Marc Jeannerod (FR)
- UK Dementia Research Institute (GB)
- Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (DE)
- Hertie Institute for Clinical Brain Research (DE)
- University Hospital Carl Gustav Carus (DE)
- University College London (GB)
- University of Rostock (DE)
- Imperial College London (GB)
- University of Aveiro (PT)
- Technical University of Munich (DE)
- University of Göttingen (DE)
- Technische Universität Dresden (DE)
- Charité - Universitätsmedizin Berlin (DE)
- University of Tübingen (DE)
- Ludwig-Maximilians-Universität München (DE)
- Otto-von-Guericke-Universität Magdeburg (DE)
- University of Edinburgh (GB)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_102595
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00