Functional impairment in association with biofluid biomarkers of Alzheimer's disease in dementia‐free older adults

Our cross-sectional findings contribute to the limited research on the association of FI with CSF biomarkers of AD in dementia-free older adults. Operationalizing FI-related risk based on persistence enhances prognostication and identifies high-risk individuals with greater burden of underlying AD pathology than those with transient FI or no FI. This approach may offer a more accurate method for early detection and stratification of at-risk individuals, potentially guiding interventions before the onset of dementia.