Cognitive and Behavioral Abnormalities in FTD Mutation Carriers: Insights into Shared Mechanisms with ADD/ADHD Disorder

Baseline impairments in cognitive function, memory, and neuropsychiatric profiles distinguish converters from non-converters, highlighting overlaps between ADD/ADHD traits and prodromal FTD. These findings suggest shared neurobiological mechanisms and underscore the need for mutation-specific studies to further explore the neurodevelopmental factors driving FTD progression.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70857_105621
Primary Topic
Attention Deficit Hyperactivity Disorder
Type
article
Field-Weighted Citation Impact
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article

Cognitive and Behavioral Abnormalities in FTD Mutation Carriers: Insights into Shared Mechanisms with ADD/ADHD Disorder

Hsiung Gd, Ian R. Mackenzie, Yara Alkhodair, Brad F Boeve et al.
Alzheimer s & Dementia
Attention Deficit Hyperactivity Disorder
article

Cognitive and Behavioral Abnormalities in FTD Mutation Carriers: Insights into Shared Mechanisms with ADD/ADHD Disorder

Hsiung Gd, Ian R. Mackenzie, Yara Alkhodair, Brad F Boeve, Emily Dwosh, Adam L. Boxer, Howard J. Rosen
article en

Abstract

Baseline impairments in cognitive function, memory, and neuropsychiatric profiles distinguish converters from non-converters, highlighting overlaps between ADD/ADHD traits and prodromal FTD. These findings suggest shared neurobiological mechanisms and underscore the need for mutation-specific studies to further explore the neurodevelopmental factors driving FTD progression.

Alzheimer s & DementiaVol. 21(S3)
University of British Columbia Hospital (CA), Vancouver Coastal Health (CA), University of British Columbia (CA), University of California, San Francisco (US), University Memory and Aging Center (US), Positive Living Society of British Columbia (CA), Mayo Clinic in Arizona (US)
Reduced inequalities
Openalex Percentile: Top 33%
Attention Deficit Hyperactivity Disorder
DOIOpen Access PDFOpenAlex
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Cognitive and Behavioral Abnormalities in FTD Mutation Carriers: Insights into Shared Mechanisms with ADD/ADHD Disorder — Hsiung Gd, Ian R. Mackenzie, et al. · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS