33P High-dimensional spatial profiling of the tumor immune microenvironment (TIME) in recurrent/metastatic head and neck squamous cell carcinoma (HNSCC) reveals predictive biomarkers of immunotherapy

Recurrent/metastatic HNSCC responds poorly to PD-1/PD-L1 blockade, partly due to lacking predictive biomarkers. The heterogeneous, immunosuppressive TIME necessitates high-resolution spatial profiling to uncover actionable immune correlates.

Authors

Institutions

Publication Details

Journal
Immuno-Oncology Technology
Published
2025-12-01
DOI
https://doi.org/10.1016/j.iotech.2025.101116
Primary Topic
Single-cell and spatial transcriptomics
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

33P High-dimensional spatial profiling of the tumor immune microenvironment (TIME) in recurrent/metastatic head and neck squamous cell carcinoma (HNSCC) reveals predictive biomarkers of immunotherapy

E.B. Saada, C. Rey, O. Odin, N. Karpinich et al.
Immuno-Oncology Technology
Single-cell and spatial transcriptomics
article

33P High-dimensional spatial profiling of the tumor immune microenvironment (TIME) in recurrent/metastatic head and neck squamous cell carcinoma (HNSCC) reveals predictive biomarkers of immunotherapy

E.B. Saada, C. Rey, O. Odin, N. Karpinich, J. Kim, F. Peyraud, R. Cheikh, O. Lara, A. Italiano, A. Bessede, A.B. Sudaka, S. Le Moulec, S. Yadavilli, J-P. Guégan, C. Pignon
article en

Abstract

Recurrent/metastatic HNSCC responds poorly to PD-1/PD-L1 blockade, partly due to lacking predictive biomarkers. The heterogeneous, immunosuppressive TIME necessitates high-resolution spatial profiling to uncover actionable immune correlates.

Immuno-Oncology TechnologyVol. 28
Clinique du Sport (FR), GlaxoSmithKline (United States) (US), Institut Bergonié (FR), Bioinformatics Institute (RU), Centre Antoine Lacassagne (FR), Université Laval (CA)
Good health and well-being
Openalex Percentile: Top 36%
Single-cell and spatial transcriptomics
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.

33P High-dimensional spatial profiling of the tumor immune microenvironment (TIME) in recurrent/metastatic head and neck squamous cell carcinoma (HNSCC) reveals predictive biomarkers of immunotherapy — E.B. Saada, C. Rey, et al. · Immuno-Oncology Technology (2025) | TGRS Research Map | TGRS